Abstract and subjects
Isotope dilution mass spectrometry using traceable standards as spikes coupled with isotope ratio measurements by thermal ionization or inductively coupled plasma mass spectrometer instruments is the preferred methodology for element content determinations and isotopic composition measurements in a variety of applications, especially those involving highly radioactive isotopes like the actinide elements. This assay measurement technique takes advantage of the sensitivity of modern mass spectrometry instrumentation to minimize the amount of material utilized for the measurement and enables the measurement sequence to be automated, with minimal intervention from analyst during the measurement process. LA-UR-20-28878.