Abstract and subjects
We have developed large-scale efficient procedures for the conversion of commercially available [C-13]- or [H-2(3),C-13]methanol and (CO2)-C-13 or C-13-labeled bromoacetic acid to 2-(phenylthio)[1,2-C-13(2)]-, [1-C-13]-, and [2-C-13] acetic acid. The resulting derivatives are versatile, chemically stable, and nonvolatile two-carbon labeling precursors. We have used the C-13-isotopomers of 2-(phenylthio) acetic acid in the synthesis of C-13-labeled acrylic acid, methacrylic acid, and trans-crotonic acid.