Abstract and subjects
13C labeled (>M + 4) metabolites of nitrogen and sulfur‐based chemical warfare agent metabolites were prepared from readily available and 13C labeled commercial starting materials. The new chemical routes are efficient in the number of chemical steps, can be scaled to afford gram quantities, and occur in good yields on the basis of the 13C label. These labeled compounds are useful as internal standards in mass spectrometry for monitoring chemical warfare agents and their metabolites. Published 2012. This article is a US Government work and is in the public domain in the USA.
13C‐labeled ethyl bromoacetate and bromoethanol were used as starting material for the synthesis of a series of 13C‐labeled sulfur and nitrogen‐based mustard metabolites. These labeled derivatives are used as mass spectrometry standards for the indirect detection of the potential presence of chemical warfare agents.